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Release SC11 (19.10.2021)


ConsensusPathDB-yeast integrates interaction networks in Saccharomyces cerevisiae including binary and complex protein-protein, genetic, metabolic, signaling, gene regulatory and drug-target interactions, as well as biochemical pathways. Data originate from currently 14 public resources for interactions (listed below) and interactions that we have curated from the literature. The interaction data are integrated in a complementary manner (avoiding redundancies), resulting in a seamless interaction network containing different types of interactions.

Literature:
Herwig et al. (2016) Analyzing and interpreting genome data at the network level with ConsensusPathDB
Kamburov et al. (2013) The ConsensusPathDB interaction database: 2013 update. Nucleic Acids Res.
Kamburov et al. (2011) ConsensusPathDB: toward a more complete picture of cell biology. Nucleic Acids Res.
Kamburov et al. (2009) ConsensusPathDB--a database for integrating human interaction networks. Nucleic Acids Res.
Pentchev, K. et al. (2010) Evidence mining and novelty assessment of protein-protein interactions with the ConsensusPathDB plugin for Cytoscape. Bioinformatics
A poster about ConsensusPathDB is available here.
Current statistics:

unique physical entities:23,720
unique interactions:645,741
   gene regulations:390
   protein interactions:240,208
   genetic interactions:401,317
   biochemical reactions:3,826
   drug-target interactions:0
pathways:1,264



Integrated databases:

name protein
interactions		 signaling
reactions		 metabolic
reactions		 gene
regulations		 genetic
interactions		 drug-target
interactions		 biochemical
pathways
BIND
Biogrid
CYC2008
DIP
IntAct
KEGG
MINT
MIPS-MPACT
PDB
PINdb
PTM
Reactome
Wikipathways
YeastCyc
ConsensusPathDB




Licensing information:
The use of ConsensusPathDB is free for academic users. Commercial users should contact Dr. Ralf Herwig ( herwig [at] molgen.mpg.de ). Interaction data from ConsensusPathDB is available under the license terms of each of the contributing databases listed above.
Disclaimer:
Although best efforts are always applied, the developers of ConsensusPathDB do not assume any legal responsibility for correctness or usefulness of the information in ConsensusPathDB.
Acknowledgements:
ConsensusPathDB is developed by the Bioinformatics group of the Vertebrate Genomics Department at the Max-Planck-Institute for Molecular Genetics in Berlin, Germany. The project was supported by the EMBRACE and CARCINOGENOMICS projects that are funded by the European Commission within its 6th Framework Programme under the thematic area "Life Sciences, Genomics and Biotechnology for Health" (LSHG-CT- 2004-512092 and LSHB-CT-2006-037712); 7th Framework Programme project APO-SYS (HEALTH-F4-2007-200767); German Federal Ministry of Education and Research within the 65 NGFN-2 program (SMP-Protein, FKZ01GR0472); Max Planck Society within its International Research School program (IMPRS-CBSC).