human    yeast    mouse


Release 26 (11.05.2013)

Read about the newest developments
of ConsensusPathDB in the 2013 update article.
Read the news page for more info on the latest release.


ConsensusPathDB-human integrates interaction networks in Homo sapiens including binary and complex protein-protein, genetic, metabolic, signaling, gene regulatory and drug-target interactions, as well as biochemical pathways. Data originate from currently 31 public resources for interactions (listed below) and interactions that we have curated from the literature. The interaction data are integrated in a complementary manner (avoiding redundancies), resulting in a seamless interaction network containing different types of interactions.

Kamburov, A. et al. (2013) The ConsensusPathDB interaction database: 2013 update. Nucleic Acids Res.
Kamburov, A. et al. (2011) ConsensusPathDB: toward a more complete picture of cell biology. Nucleic Acids Res.
Kamburov, A. et al. (2009) ConsensusPathDB--a database for integrating human interaction networks. Nucleic Acids Res.
Pentchev, K. et al. (2010) Evidence mining and novelty assessment of protein-protein interactions with the ConsensusPathDB plugin for Cytoscape. Bioinformatics
A poster about ConsensusPathDB is available here.
Current statistics:

unique physical entities:155,205
unique interactions:400,368
   gene regulations:5,787
   protein interactions:209,872
   genetic interactions:1,293
   biochemical reactions:21,184
   drug-target interactions:162,232
pathways:4,873



Integrated databases:

name protein
interactions		 signaling
reactions		 metabolic
reactions		 gene
regulations		 genetic
interactions		 drug-target
interactions		 biochemical
pathways
Reactome
Kegg
Humancyc
Pid
Biocarta
Netpath
Inoh
Ehmn
Phosphositeplus
Innatedb
Intact
Dip
Mint
Hprd
Corum
Biogrid
Mips-mppi
Bind
Matrixdb
Pindb
Spike
Pig
Phosphopoint
Pdzbase
Pharmgkb
Smpdb
Signalink
Drugbank
Ttd
Wikipathways
Chembl
ConsensusPathDB




Licensing information:
The use of ConsensusPathDB is free for academic users. Commercial users should contact Dr. Atanas Kamburov (kamburov [at] molgen.mpg.de) or Dr. Ralf Herwig ( herwig [at] molgen.mpg.de ). Interaction data from ConsensusPathDB is available under the license terms of each of the contributing databases listed above.
Disclaimer:
Although best efforts are always applied, the developers of ConsensusPathDB do not assume any legal responsibility for correctness or usefulness of the information in ConsensusPathDB.
Acknowledgements:
ConsensusPathDB is being developed by the Bioinformatics group of the Vertebrate Genomics Department at the Max-Planck-Institute for Molecular Genetics in Berlin, Germany. The project was supported by the EMBRACE and CARCINOGENOMICS projects that are funded by the European Commission within its 6th Framework Programme under the thematic area "Life Sciences, Genomics and Biotechnology for Health" (LSHG-CT- 2004-512092 and LSHB-CT-2006-037712); 7th Framework Programme project APO-SYS (HEALTH-F4-2007-200767); German Federal Ministry of Education and Research within the 65 NGFN-2 program (SMP-Protein, FKZ01GR0472); Max Planck Society within its International Research School program (IMPRS-CBSC).