human    yeast    mouse


Release 22 (15.01.2012)

Newly integrated databases: DrugBank and PIN.
New interaction types: genetic interaction and drug-target interaction.
Over-representation and enrichment analysis with protein complexes as functional gene sets.
Read the news page for more info.


unique physical entities:51,425
unique functional interactions:169,918
pathways:3,281


ConsensusPathDB-human integrates functional interaction networks in Homo sapiens including binary and complex protein-protein, genetic, metabolic, signaling, gene regulatory and drug-target interactions, as well as biochemical pathways. Data originate from currently 29 public resources for functional interactions (listed below) and interactions that we have curated from the literature. The interaction data are integrated in a complementary manner (avoiding redundancies), resulting in a seamless interaction network containing different types of interactions.

If you use ConsensusPathDB, please cite:




Integrated databases:

name version protein
interactions
signaling
reactions
metabolic
reactions
gene
regulations
genetic
interactions
drug-target
interactions
biochemical
pathways
Reactome 39
Kegg 61.0
Humancyc 15.5
Pid 2012_01_12
Biocarta 2009_05_12
Netpath 14.1.2012
Inoh 14.1.2012
Ehmn 14.1.2012
Phosphositeplus 14.1.2012
Innatedb 14.1.2012
Intact-ss 2012-01-01Z
Intact-ls 2005-11-01Z
Dip 2011-10-27
Mint 2010-12-17+01:00
Hprd I_041210
Corum 15.1.2012
Biogrid 3.1.84
Mips-mppi 15.1.2012
Bind 15.1.2012
Matrixdb 20100826
Pin 15.1.2012
Spike 15.1.2012
Pig 15.1.2012
Phosphopoint 15.1.2012
Pdzbase 15.1.2012
Pharmgkb 15.1.2012
Smpdb 15.1.2012
Signalink 15.1.2012
Drugbank 15.1.2012
Wikipathways 15.1.2012




Licensing information:
The use of ConsensusPathDB is free for academic users. Commercial users should contact Dr. Ralf Herwig ( herwig [at] molgen.mpg.de ). Interaction data from ConsensusPathDB is available under the license terms of each of the contributing databases listed above.
Disclaimer:
Although best efforts are always applied, the developers of ConsensusPathDB do not assume any legal responsibility for correctness or usefulness of the information in ConsensusPathDB.
Acknowledgements:
ConsensusPathDB is being developed by the Bioinformatics group of the Vertebrate Genomics Department at the Max-Planck-Institute for Molecular Genetics in Berlin, Germany. The project was supported by the EMBRACE and CARCINOGENOMICS projects that are funded by the European Commission within its 6th Framework Programme under the thematic area "Life Sciences, Genomics and Biotechnology for Health" (LSHG-CT- 2004-512092 and LSHB-CT-2006-037712); 7th Framework Programme project APO-SYS (HEALTH-F4-2007-200767); German Federal Ministry of Education and Research within the 65 NGFN-2 program (SMP-Protein, FKZ01GR0472); Max Planck Society within its International Research School program (IMPRS-CBSC).