human    yeast    mouse


Release 35 (05.06.2021)


ConsensusPathDB-human integrates interaction networks in Homo sapiens including binary and complex protein-protein, genetic, metabolic, signaling, gene regulatory and drug-target interactions, as well as biochemical pathways. Data originate from currently 30 public resources for interactions (listed below) and interactions that we have curated from the literature. The interaction data are integrated in a complementary manner (avoiding redundancies), resulting in a seamless interaction network containing different types of interactions.

Literature:
Herwig, R. et al.. Analyzing and interpreting genome data at the network level with ConsensusPathDB. (2016) Nature Protocols 11, 1889-1907.
Kamburov, A. et al. (2013) The ConsensusPathDB interaction database: 2013 update. Nucleic Acids Res.
Kamburov, A. et al. (2011) ConsensusPathDB: toward a more complete picture of cell biology. Nucleic Acids Res.
Kamburov, A. et al. (2009) ConsensusPathDB--a database for integrating human interaction networks. Nucleic Acids Res.
Pentchev, K. et al. (2010) Evidence mining and novelty assessment of protein-protein interactions with the ConsensusPathDB plugin for Cytoscape. Bioinformatics
Current statistics:

unique physical entities:108,821
unique interactions:717,569
   gene regulations:18,912
   protein interactions:616,304
   genetic interactions:7,936
   biochemical reactions:25,046
   drug-target interactions:49,371
pathways:5,578



Integrated databases:

name protein
interactions
signaling
reactions
metabolic
reactions
gene
regulations
genetic
interactions
drug-target
interactions
biochemical
pathways
BIND
BioCarta
Biogrid
CORUM
DIP
EHMN
HPRD
HumanCyc
INOH
InnateDB
IntAct
KEGG
MINT
MIPS-MPPI
MatrixDB
NetPath
PDB
PDZBase
PID
PIG
PINdb
PharmGKB
PhosphoPOINT
PhosphoSitePlus
Reactome
SMPDB
Signalink
Spike
TTD
Wikipathways

ConsensusPathDB




Licensing information:
The use of ConsensusPathDB is free for academic users. Commercial users should contact Dr. Ralf Herwig ( herwig [at] molgen.mpg.de ). Interaction data from ConsensusPathDB is available under the license terms of each of the contributing databases listed above.
Disclaimer:
Although best efforts are always applied, the developers of ConsensusPathDB do not assume any legal responsibility for correctness or usefulness of the information in ConsensusPathDB.
Acknowledgements:
ConsensusPathDB is developed and maintained by the Bioinformatics group of the Computational Molecular Biology Department at the Max-Planck-Institute for Molecular Genetics in Berlin, Germany. The work was supported by the German Federal Ministry of Education and Research (BMBF) with the grant SafetyNet (No. 161L0242A), the European Commission under its Horizon 2020 Framework program with the grant PHINDaccess (No. 811034), and by the Max Planck Society within its International Research School program (IMPRS-CBSC).